Fiber density and cross-sectional area

Fiber density and cross-sectional area is associated with cognitive function in humans.

“In probable AD patients, FDC values of IFOF_L were positively correlated with global cognitive function, attention and calculation abilities, executive and visuospatial functions, and information processing speed.”

Humansin probable AD patientsleft inferior fronto-occipital fasciculus

Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed

Brain and behavior·Mar 1, 2026