ESC Congress 2026 Abstract
Klotho preserves contraction timing in human heart slices
Failing heart slices from eight patients preserved contraction timing and improved calcium handling when treated with soluble Klotho for two weeks.Failing heart slices from eight patients preserved contraction timing and improved calcium handling when treated with soluble Klotho for two weeks.
Human cell studyInterventions
Who was studied8 patients with elevated BNP and frequent renal dysfunction, 2 weeks
What changedTreated heart slices preserved contraction timing, whereas untreated slices showed prolonged time-to-peak
The catchThe pig experiment examined genetic Klotho deficiency, not Klotho treatment