Fatigue
Biomarker2 papers3 findings
- Humans2
Associations
3Dementia
upin humans1HR 1.51
1 study
Dementia
upin humans1HR 1.51
Fatigue raises the risk of dementia in humans (HR 1.51 (95% CI, 1.42-1.60)).
Humanscompared with neither exposuren = 484,749
Prevalent Stroke, Fatigue, and Incident Dementia Risk in the UK Biobank · Cerebrovascular diseases (Basel, Switzerland) · 5 Sep 2026
ADL dependence
upin humans1
1 study
ADL dependence
upin humans1
Fatigue is associated with ADL dependence in humans.
“Between age 70-100, fatigue was significantly associated with numerous cross-sectional health and functional measures, and subsequent deterioration for loneliness, SRH, ADL dependence, and physical activity.”
Humans
Fatigue, Health and Mortality from age 70-100 · GSA 2025 abstract · 31 Dec 2025
Mortality
upin humans1
1 study
Mortality
upin humans1
Fatigue raises the risk of mortality in humans.
“After adjusting for known mortality risk factors, fatigue at age 70, 85 and 90 was associated with increased mortality.”
Humansadjusted for gender, education, CCI
Fatigue, Health and Mortality from age 70-100 · GSA 2025 abstract · 31 Dec 2025
Funding
National Cancer InstituteUS$1.1mNational Institute on AgingUS$124.2k4 grants since 2023
National Cancer InstituteUniversity of Maryland BaltimoreUS$638.5k2026–2031
National Cancer InstituteUniversity of Maryland BaltimoreUS$363.6k2024–2028
National Institute on AgingUniversity of Maryland BaltimoreUS$124.2k2023–2028
National Cancer InstituteUniversity of RochesterUS$133.5k2026–2028
Latest
84Microbial compounds limited muscle loss in aged mice
In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.
Fluvoxamine may ease fatigue in adults with long COVID
Mean Fatigue Severity Scale scores were 0.43 points lower than placebo at day 60 and 0.58 points lower at day 90.Mean Fatigue Severity Scale scores were 0.43 points lower than placebo at day 60 and 0.58 points lower at day 90.