fALFF

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White matter hyperintensities

mediatesin humans1downin humans1

1 study

White matter hyperintensities mediate fALFF in humans (p_fdr < 0.05).
“Mediation analysis revealed statistically significant ( p fdr < 0.05) effects of global WMH load on the impact of age on fALFF”
Humanshealthy agingbrainn = 557
The mediating effect of white matter hyperintensities on spontaneous brain activity during aging
AAIC 2025 abstract9 Jan 2026
White matter hyperintensities decrease fALFF in humans (p_fdr < 0.05).
“fALFF exhibited significant ( p fdr < 0.05) negative correlations with both age and WMHs across the cortex”
Humanshealthy agingbrainn = 557
The mediating effect of white matter hyperintensities on spontaneous brain activity during aging
AAIC 2025 abstract9 Jan 2026

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