Epigenetic IL-6

There is 1 paper on epigenetic IL-6 in aging research: 1 trial in people.

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Emtricitabine + tenofovir alafenamide

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Emtricitabine + tenofovir alafenamide decreases epigenetic IL-6 in humans (FTC/TAF study arm) (-0.058, p=0.029).
“significant reductions in epigenetic IL-6 (-0.058, p=0.029)”
Human trialFTC/TAF study arm200 mg/25 mg12 weeksn = 36
An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics
medRxiv : the preprint server for health sciencesMar 26, 2026Preprint

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medRxivApr 3

An FDA-Approved Tenofovir Alafenamide-Based Antiretroviral Therapy Reduces Biological Age in Healthy Adults: First Human Proof-of-Concept for Retrotransposon-Targeted Gerotherapeutics

Preprint: randomized trial in 43 peopleInterventions