Empirical Dietary Index for Slower Epigenetic Aging

1. Empirical Dietary Index for Slower Epigenetic Aging is associated with functional limitations in humans.

   “In HRS and a UK aging cohort (n=4,895), EDISEA was associated with lower risks of several aging-related diseases and functional limitations.”

   HumansHRS and a UK aging cohort

   A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

   medRxiv·25 Feb 2026Preprint

1. Empirical Dietary Index for Slower Epigenetic Aging is associated with mortality in humans.

   “We externally validated EDISEA in an independent US cohort (n=23,830), where it showed consistent associations with several epigenetic clocks and lower all-cause mortality risk.”

   HumansIndependent US validation cohortn = 23,830

   A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

   medRxiv·25 Feb 2026Preprint

1. Empirical Dietary Index for Slower Epigenetic Aging is associated with GrimAge in humans (4.65-year deceleration in the highest versus lowest quintile).

   “Participants in the highest versus lowest EDISEA quintile had 4.65-year deceleration in GrimAge (P value <0.001).”

   HumansHighest versus lowest EDISEA quintile in HRSn = 7,398

   A data-driven dietary pattern anchored to slower epigenetic aging is associated with a spectrum of aging-related health outcomes

   medRxiv·25 Feb 2026Preprint

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