Driver mutation frequency

1. Driver mutation frequency was not clearly linked with metachronous neoplasia in index adenomas, after polypectomy with surveillance colonoscopy within 6 years (p=0.901).

   “neither mutation frequency (p=0.901), nor median tumour mutation burden (TMB) (2.27 vs 2.15 mut/Mb, p=0.242), in index adenomas was associated with the development of metachronous lesions”

   Humansin index adenomas, after polypectomy with surveillance colonoscopy within 6 yearscolorectal adenoma

   Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening setting

   medRxiv·Aug 11, 2026Preprint

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