Metachronous neoplasia

1. Tumor mutational burden was not clearly linked with metachronous neoplasia in index adenomas, after polypectomy with surveillance colonoscopy within 6 years (2.27 vs 2.15 mut/Mb, p=0.242).

   “neither mutation frequency (p=0.901), nor median tumour mutation burden (TMB) (2.27 vs 2.15 mut/Mb, p=0.242), in index adenomas was associated with the development of metachronous lesions”

   Humansin index adenomas, after polypectomy with surveillance colonoscopy within 6 yearscolorectal adenoma

   Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening setting

   medRxiv·Aug 11, 2026Preprint

More on Tumor mutational burden

1. Driver mutation frequency was not clearly linked with metachronous neoplasia in index adenomas, after polypectomy with surveillance colonoscopy within 6 years (p=0.901).

   “neither mutation frequency (p=0.901), nor median tumour mutation burden (TMB) (2.27 vs 2.15 mut/Mb, p=0.242), in index adenomas was associated with the development of metachronous lesions”

   Humansin index adenomas, after polypectomy with surveillance colonoscopy within 6 yearscolorectal adenoma

   Classical driver mutations are not associated with metachronous lesion risk in patients undergoing post-polypectomy surveillance following removal of conventional adenomas in a bowel screening setting

   medRxiv·Aug 11, 2026Preprint

More on Driver mutation frequency