DNA methylation variation
3 papers study it12 more mention it3 findings
- Humans3
Associations
3Age
mixedin humans1
1 study
Age
mixedin humans1
Age predicts DNA methylation variation in humans.
“We show that aging is a primary predictor of DNA methylation variation, surpassing the influence of factors such as sex and schizophrenia diagnosis, among others.”
Humansbrain neurons and non-neuronal cells, primarily oligodendrocytes
Human Brain Aging is Associated with Dysregulation of Cell-Type Epigenetic Identity
bioRxiv : the preprint server for biologyPreprint
Epigenetic clock sites
upin humans1
1 study
Epigenetic clock sites
upin humans1
Epigenetic clock sites are associated with DNA methylation variation in humans.
“clock sites (i) diverge widely in their developmental trajectories, often showing non-linear change over time”
Humansn = 2,348
What makes clocks tick? Characterizing developmental dynamics of adult epigenetic clock sites
bioRxiv : the preprint server for biologyPreprint
Genetic variation
mixedin humans1
1 study
Genetic variation
mixedin humans1
genetic variation is associated with DNA methylation variation in humans (Mean heritability 19%).
“Heritability estimates vary across the genome (mean=19%)”
Humansindividuals from twin familieswhole bloodn = 2,603
Genetic and environmental influences interact with age and sex in shaping the human methylome
Nature communications
Funding
1 grant since 2023UKRI | Medical Research Council£2.2m