DN2-associated transcriptional state

DN2-associated transcriptional state is associated with age-associated B cell developmental trajectories in silico.

“three pathways from naive, IgM + memory B cells and switched-memory B cells mature through a DN2-associated transcriptional state that precedes age-associated B cells.”

In silicoHealthy ageing; inferred pathways originating from naive, IgM-positive memory and switched-memory B cellsB cell

Multimodal computational framework identifies B cell convergence in autoimmunity and ageing

bioRxiv (Cold Spring Harbor Laboratory)·3 Jul 2026Preprint