CSF alpha-synuclein seed amplification assay

There are 2 papers on CSF alpha-synuclein seed amplification assay in aging research: 2 observational studies in people. The newest story, Oct 28, 2026: “Combined sleep and smell signs linked to Parkinson’s marker”.

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medRxiv

Combined sleep and smell signs linked to Parkinson’s marker

A spinal-fluid test was positive in 94% with a confirmed dream-enactment sleep disorder and reduced smell, versus 40% with the disorder but no reduced smell.A spinal-fluid test was positive in 94% with a confirmed dream-enactment sleep disorder and reduced smell, versus 40% with the disorder but no reduced smell.

Preprint: cohort studyParkinson's disease