Costimulatory and adhesion molecule expression

1. Caloric restriction decreases costimulatory and adhesion molecule expression in mice.

   “The increase in costimulatory (CD80 and CD86) and adhesion (ICAM-1, PGP-1, LFA-1, and Mac-1) in peripheral blood mononuclear cells was also attenuated by food restriction and to a lesser extent by fish oil alone.”

   Animalsin lupus-prone (NZBxNZW)F1 miceperipheral blood mononuclear cells

   Age associated alterations in costimulatory and adhesion molecule expression in lupus-prone mice are attenuated by food restriction with n-6 and n-3 fatty acids

   Journal of clinical immunology·Sep 1, 2004

More on Caloric restriction