Cortical mean diffusivity

1. p-Tau217 increases cortical mean diffusivity in humans (p <0.05, FDR-corrected).

   “the ptau217+ group showed significantly higher cortical MD in bilateral medial temporal (amygdala and hippocampus) and insular regions (insular and opercular cortices) compared to ptau217-”

   Humanscognitively unimpairedbilateral medial temporal and insular regions65% femalesn = 1,029

   Increased cortical mean diffusivity in cognitively unimpaired individuals with elevated plasma ptau217

   AAIC 2025 abstract·26 Dec 2025

More on p-Tau217

1. Cortical mean diffusivity is associated with C-reactive protein in humans.

   “while the association was negative and more widespread for hsCRP”

   Humanscortexn = 964

   Cortical integrity changes with cognition, plasma biomarkers and APOE4 status across the adult healthy lifespan

   AAIC 2025 abstract·8 Jan 2026

More on C-reactive protein

1. Cortical mean diffusivity is associated with cognitive function in humans.

   “cMD was positively correlated with PACC scores and both pTau‐181 and NFL concentrations in prefrontal regions”

   Humansprefrontal cortexn = 964

   Cortical integrity changes with cognition, plasma biomarkers and APOE4 status across the adult healthy lifespan

   AAIC 2025 abstract·8 Jan 2026