Combined amyloid and P-TAU181 positivity
Biomarker3 findings
Associations
3EOAD signature, precuneus, and superior temporal sulcus bank cortical thickness
downin humans1
1 study
EOAD signature, precuneus, and superior temporal sulcus bank cortical thickness
downin humans1
Combined amyloid and P-TAU181 positivity is associated with EOAD signature, precuneus, and superior temporal sulcus bank cortical thickness in humans.
Humanssubjective cognitive declinecerebral cortex
Brain thinning detected before dementia in people under 65 · Journal of neurology · 7 Oct 2026
EOAD signature, precuneus, and superior temporal sulcus bank cortical thickness →
Hippocampal volume
downin humans1
1 study
Hippocampal volume
downin humans1
Combined amyloid and P-TAU181 positivity is associated with hippocampal volume in humans.
Humansmild cognitive impairmenthippocampus
Brain thinning detected before dementia in people under 65 · Journal of neurology · 7 Oct 2026
Cortical thickness
downin humans1
1 study
Cortical thickness
downin humans1
Combined amyloid and P-TAU181 positivity is associated with cortical thickness in humans.
Humansmild cognitive impairment; A+T1+ compared with A+T1- profilescerebral cortex
Brain thinning detected before dementia in people under 65 · Journal of neurology · 7 Oct 2026
Latest
1Brain thinning detected before dementia in people under 65
An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.An observational study of 292 people under 65 linked two positive Alzheimer’s-related spinal-fluid tests to earlier and more extensive thinning.