Clonal hematopoiesis clone size

1. Clonal hematopoiesis clone size has no effect on circulating tumor DNA in humans.

   “CH clone size showed high concordance between PB and cfDNA (R2=0.59, P<0.0001) but was not associated with circulating tumor DNA (ctDNA) concentration (P-values 0.25-0.86).”

   HumansHigh-risk primary large B-cell lymphoma

   Clonal hematopoiesis and cell-free DNA characteristics in patients with high-risk large B-cell lymphomas

   medRxiv·15 Oct 2026Preprint

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1. Somatic mutation count is associated with clonal hematopoiesis clone size in humans.

   “we identified a strong correlation between large CH size and the number of mutations per individual”

   Humans

   The impact of age and number of mutations on the size of clonal hematopoiesis

   Proceedings of the National Academy of Sciences of the United States of America·15 Feb 2024

More on Somatic mutation count