Clock-like mutational signatures

1 paper1 finding

Associations

1

Chronological age

upin humans1

1 study

Chronological age is associated with clock-like mutational signatures in humans.
“accumulate approximately linearly with chronological age across nearly all normal human somatic tissues.”
Reviewnormal human somatic tissues
Clock-like mutational signatures: Linking ageing to endogenous cancer risk
Ageing research reviewsApr 22, 2026

Latest

3 in 12 months

Ageing Research ReviewsApr 25

Clock-like mutational signatures: Linking ageing to endogenous cancer risk

ReviewMechanisms

Genes, Chromosomes & CancerJan 21

Endogenous Processes Underlying Clock-Like Mutational Signatures

Experiments in miceMechanisms

Nature AgingNov 18

Single-cell analysis of the somatic mutational landscape in human chondrocytes during aging and in osteoarthritis

Cross-sectional study of 17 peopleBones and joints

GeroScienceMar 15

Somatic mutations in aging and disease

ReviewMechanisms

Molecular Biology and EvolutionOct 4

Evolution of the Mutation Spectrum Across a Mammalian Phylogeny

Computational studyMechanisms

medRxivMay 26

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing data

Preprint: computational studyMechanisms

NatureApr 22

Somatic genomic changes in single Alzheimer's disease neurons

Study in peopleMechanisms

Research SquareOct 7

Somatic mutations in single human cardiomyocytes demonstrate accelerated age-related DNA damage and cell fusion

Preprint: study in peopleMechanisms