Chromosome 9q CNLOH

1. NOTCH1 is associated with chromosome 9q CNLOH in human cells (up to ~35% of epithelial cells).

   “We further observed copy-neutral loss of heterozygosity (CNLOH) events on chromosome 9q that spanned the NOTCH1 locus in up to ~35% of epithelial cells.”

   Cellsphenotypically normal esophagusesophageal epitheliumn = 4

   Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus

   bioRxiv : the preprint server for biology·13 Oct 2025Preprint

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