Alzheimer's & Dementia
Mismatched Alzheimer's tests linked to distinct risk patterns
An observational analysis of 594 and 475 cognitively normal adults found different blood-protein patterns depending on which Alzheimer's test was positive.An observational analysis of 594 and 475 cognitively normal adults found different blood-protein patterns depending on which Alzheimer's test was positive.
Cohort · 332 peopleBiomarkers
Who was studied332 cognitively normal adults with diagnostic follow-up, mean 3.06 years
What changedMild cognitive impairment or dementia was more likely with blood-positive/PET-negative than double-negative tests (hazard ratio 4.44)
The catchUnmeasured inflammation and mixed pathology could contribute to the blood-positive, PET-negative biomarker pattern