CDKN2A, IL1B, MMP1, AHR, CYP1A1, and CYP1B1 expression

1. Cigarette smoke and heated tobacco product aerosol increases CDKN2A, IL1B, MMP1, AHR, CYP1A1, and CYP1B1 expression in human cells.

   “Repeated exposure to RC and HTP (HTP at a 10-fold higher concentration) increased the expression levels of CDKN2A, IL1B, MMP1, AHR, CYP1A1, and CYP1B1,”

   CellsTIG-1 lung fibroblastsHTP at a 10-fold higher concentration than RCrepeated exposure

   Effects of Aerosol Extract From Heated Tobacco Products on Senescence-Associated Gene Expression in Human Lung Fibroblasts

   Geriatrics & gerontology international·1 Mar 2026

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