CD8+ EMRA to CD4+ naive T cell ratio

1. Adverse childhood experiences are associated with CD8+ EMRA to CD4+ naive T cell ratio in humans (+0.16 higher, 95% CI: 0.05, 0.27).

   “and a 0.16 higher CD8+ EMRA:CD4+ Naïve ratio (95% CI: 0.05, 0.27), adjusting for age.”

   Humans3+ traumas before age 18 compared to nonewhole bloodfemales

   Early Life Trauma and Immune Aging: Evidence of a Biological Threshold in Older Women · GSA 2025 abstract · 31 Dec 2025

Adverse childhood experiences →