CD8+ EMRA:naive ratio

CD8+ EMRA:naive ratio impairs cognitive function in humans (-0.050 point/year per SD (95% CI: -0.066 to -0.033, P < 0.001)).

“a higher CD8 + EMRA: Naïve ratio was significantly associated with accelerated cognitive decline (-0.050 point/year per SD; 95% CI: -0.066 to -0.033, P < 0.001).”

Humans6-yearn = 7,444

Peripheral immunosenescence biomarkers and longitudinal cognitive decline: a large population-based study

npj aging·2 Jun 2026