CD4+ cytotoxic T lymphocytes

1 paper studies it4 more mention it2 findings

Effects

1

Clonal expansion

upin humans1

1 study

CD4+ cytotoxic T lymphocytes increase clonal expansion in humans (15 to 35% of the entire CD4 T cell population).
“CD4 CTLs had accumulated through massive clonal expansion, with the most frequent clonotypes accounting for 15 to 35% of the entire CD4 T cell population.”
Humanssupercentenariansperipheral bloodn = 2
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians
Proceedings of the National Academy of Sciences of the United States of AmericaNov 12, 2019

Associations

1

Supercentenarians

upin humans1

1 study

Supercentenarians are associated with CD4+ cytotoxic T lymphocytes in humans.
“supercentenarians harbor expanded, nonexhausted CD4+ cytotoxic T lymphocytes”
Reviewin supercentenarians
Uncovering an adaptive immune hallmark of extreme longevity
Trends in genetics : TIGAug 20, 2026

Latest

2 papers in 12 months

Trends in GeneticsAug 20

Uncovering an adaptive immune hallmark of extreme longevity

CommentaryImmune response

Cell ReportsAug 19

CD4 CTLs in supercentenarians: Signs of adaptive expansion in healthy aging

Cohort study in peopleMechanisms

Aging CellJul 29

Single-Cell Sequencing Reveals That CD4⁺ T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia

Study in peopleCellular senescence

Advanced ScienceJul 28

Osteoblast-CD4⁺ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age-Related Bone Loss

Experiments in miceSirtuin signaling

PNASNov 14

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

Cross-sectional study of 7 peopleCD4

Immune response1