Caspase-3-positive fraction of NeuN-positive neurons

Older age is associated with Caspase-3-positive fraction of NeuN-positive neurons in humans (young 42%, middle 82%, elderly 89%).

“the fraction of Caspase-3+ among NeuN+ neurons in the penumbra rose (young 42%, middle 82%, elderly 89%).”

Humansischemic stroke; death ≤7 days post-onsetfrontal cortex penumbran = 154

Aging Rewires Neuronal Metabolism, Exacerbating Cell Death After Ischemic Stroke: A Hidden Reason for the Failure of Neuroprotection

International journal of molecular sciences·21 Dec 2025