C2

1. C2 is associated with worsened outcomes over 2 years in community-based KFACS cohort (p = 0.002).

   “were elevated in individuals with worsened outcomes over 2 years (p = 0.002 and p = 0.034, respectively)”

   Humansin community-based KFACS cohortplasma extracellular vesicle-associated protein2 yearsn = 90

   Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts

   Journal of cachexia, sarcopenia and muscle·Jul 21, 2026

1. C2 is associated with gait speed decline in community-based KFACS cohort (β = -0.302, p = 0.006).

   “EV-associated complement proteins, particularly C2 and C4B, were strongly associated with declines in gait speed (β = -0.302, p = 0.006; β = -0.231, p = 0.028, respectively)”

   Humansin community-based KFACS cohortplasma extracellular vesicle-associated protein2 yearsn = 90

   Plasma Extracellular Vesicles-Derived Complement Proteins as Biomarkers of Sarcopenia Progression in Longitudinal Cohorts

   Journal of cachexia, sarcopenia and muscle·Jul 21, 2026

1. Diastolic oscillation amplitude is associated with C2 in humans.

   “we found a strong linear correlation with C2”

   Humans

   The Diastolic Oscillation Amplitude Used as an Arterial Aging Indicator

   Vascular health and risk management·Apr 4, 2023

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1. C2 is associated with type 2 diabetes in humans (non-pregnant) (OR 1.051, CI 1.019-1.085).

   “C2 (OR = 1.051, CI = 1.019-1.085, p = 0.002)”

   Humansnon-pregnantfemalesn = 808

   Non-Invasive radial pressure wave analysis may digitally predict women's risks of type 2 diabetes (T2DM): A case and control group study

   PloS one·Oct 29, 2021

More on Type 2 diabetes