Brain AgeGap

1 paper2 findings

Associations

Preclinical Alzheimer's Cognitive Composite

downin humans1

1 study

Brain AgeGap is associated with preclinical Alzheimer's Cognitive Composite in humans (Coefficient -0.14, 95% CI -0.3 to -0.03).
“Higher baseline AgeGap z-scores (i.e., greater biological age) in the artery and brain were associated with poorer cognition,”
HumansHigher baseline brain AgeGap z-score; adjusted multilevel regression54 months50.1% femalesn = 409
Organ-specific proteomic aging and cognitive performance: Implications for risk prediction of Alzheimer's disease and related dementias in older adults
The journal of prevention of Alzheimer's disease22 Jul 2025

Repeatable Battery for the Assessment of Neuropsychological Status Total Score

downin humans1

1 study

Brain AgeGap is associated with repeatable Battery for the Assessment of Neuropsychological Status Total Score in humans (Coefficient -1.1, 95% CI -1.5 to -0.6).
“Higher baseline AgeGap z-scores (i.e., greater biological age) in the artery and brain were associated with poorer cognition,”
HumansHigher baseline brain AgeGap z-score; adjusted multilevel regression54 months50.1% femalesn = 409
Organ-specific proteomic aging and cognitive performance: Implications for risk prediction of Alzheimer's disease and related dementias in older adults
The journal of prevention of Alzheimer's disease22 Jul 2025

The Journal of Prevention of Alzheimer's Disease24 Jul

Cohort study of 409 peopleBiomarkers