Brain age gap factor polygenic score

1. Brain age gap factor polygenic score is associated with health traits in humans.

   “Phenome-wide association analyses indicated that BAG factor PGS captured associations with more health traits than individual BAG PGSs.”

   HumansMore associations than individual brain age gap polygenic scores

   Shared genetic architecture of brain age gap across 30 cohorts worldwide

   medRxiv : the preprint server for health sciences·27 Dec 2025Preprint

1. Brain age gap factor polygenic score is associated with brain age gap in humans.

   “A polygenic score (PGS) for the BAG factor showed associations with phenotypic BAGs already in childhood, with stronger links observed in adulthood.”

   HumansStronger associations in adulthood

   Shared genetic architecture of brain age gap across 30 cohorts worldwide

   medRxiv : the preprint server for health sciences·27 Dec 2025Preprint

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