Bone marrow adipose tissue volume

1. Caloric restriction increases bone marrow adipose tissue volume in mice.

   “CR-induced BMAT expansion was site-specific, being greater in tibiae than femora and absent in humeri.”

   Animals30% CRbone marrow1, 2, 4, or 6 weeks

   Caloric restriction exerts site-, sex-, and duration-dependent effects on skeletal structure and bone marrow adiposity

   The Journal of endocrinology·Apr 23, 2026

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