Biological age uncertainty

Biomarker1 paper4 findings

Humans1

Associations

Mortality

upin humans1HR 1.24–1.4

1 study

Biological age uncertainty is associated with mortality in humans (HR 1.40 (95% CI, 1.37-1.43) per SD).
Humansproteomic-derived, per standard deviation, independently of BAG
Biological age uncertainty independently predicts mortality and health decline in humans · medRxiv · 28 Sep 2026 · Preprint
Biological age uncertainty is associated with mortality in humans (HR 1.24 (95% CI, 1.23-1.26) per SD).
HumansNMR-derived, per standard deviation, independently of BAG
Biological age uncertainty independently predicts mortality and health decline in humans · medRxiv · 28 Sep 2026 · Preprint

Multimorbidity

upin humans1

1 study

Biological age uncertainty raises the risk of multimorbidity in humans.
Humansindependently of BAG
Biological age uncertainty independently predicts mortality and health decline in humans · medRxiv · 28 Sep 2026 · Preprint

Multimorbidity →

Healthspan

downin humans1

1 study

Biological age uncertainty is associated with healthspan in humans.
Humansindependently of BAG
Biological age uncertainty independently predicts mortality and health decline in humans · medRxiv · 28 Sep 2026 · Preprint

Latest

HumansPreprintAging clocks29 Sep

Biological age uncertainty independently predicts mortality and health decline in humans

Researchers derived biological age uncertainty across UK Biobank participants, finding that higher uncertainty reflects reduced physiological coherence and predicts worse health outcomes.

medRxiv · Li Y et al.

Paper