BAT oxidative metabolism

1. Gonadotropin-releasing hormone agonist decreases BAT oxidative metabolism in humans (from 1.36 ± 0.66 min−1 to 0.91 ± 0.41 min−1).

   “In premenopausal women who underwent gonadotropin-releasing hormone agonist, cold-stimulated BAT oxidative metabolism was reduced to a similar level (from 1.36 ± 0.66 min−1 to 0.91 ± 0.41 min−1) to that observed in postmenopausal women”

   Human trialacute cold exposurebrown adipose tissue6 mofemalesn = 8

   Brown adipose tissue metabolism in women is dependent on ovarian status

   American journal of physiology. Endocrinology and metabolism·Mar 13, 2024

More on Gonadotropin-releasing hormone agonist

1. Postmenopausal status decreases BAT oxidative metabolism in humans (1.28 ± 0.85 vs. 0.91 ± 0.63 min−1, P = 0.03; 84.4 ± 82.5 vs. 29.7 ± 31.4 nmol·g−1·min−1, P < 0.01).

   “During cold exposure, BAT oxidative metabolism (1.28 ± 0.85 vs. 0.91 ± 0.63 min−1, P = 0.03) and net BAT glucose uptake (84.4 ± 82.5 vs. 29.7 ± 31.4 nmol·g−1·min−1, P < 0.01) were higher in premenopausal than postmenopausal women.”

   Human trialduring acute cold exposurebrown adipose tissuefemales

   Brown adipose tissue metabolism in women is dependent on ovarian status

   American journal of physiology. Endocrinology and metabolism·Mar 13, 2024