BAG change score

1. BAG change score is associated with Aβ42/Aβ40 ratio in humans (b=‐0.35, p = 2.2 x10 ‐3).

   “lower CSF Aβ 42/40 ratio (b=‐0.35, p = 2.2 x10 ‐3 )”

   Humanssubset n=114, adjusted for sexcsfn = 114

   Divergent trajectories of brain ageing across the seventh decade predict AD pathology in a UK population‐based birth cohort · AAIC 2025 abstract · 24 Dec 2025

Aβ42/Aβ40 ratio →

1. BAG change score is associated with p-Tau217 in humans (b=0.26, p = 6.2x10 -4).

   “higher plasma p ‐tau217 (b=0.26, p = 6.2x10 ‐4 )”

   Humansadjusted for sexplasman = 414

   Divergent trajectories of brain ageing across the seventh decade predict AD pathology in a UK population‐based birth cohort · AAIC 2025 abstract · 24 Dec 2025

p-Tau217 →

1. BAG change score is associated with amyloid PET in humans (OR 1.89, p = 6.4x10 -3).

   “Higher BAG change score (i.e., accelerating brain ageing) was associated with amyloid‐PET positivity (OR 1.89, p = 6.4x10 ‐3 , Figure 2)”

   Humansadjusted for sexbrainn = 414

   Divergent trajectories of brain ageing across the seventh decade predict AD pathology in a UK population‐based birth cohort · AAIC 2025 abstract · 24 Dec 2025

Amyloid PET →