ASHS-LIA

1. ASHS-LIA raises the risk of subretinal drusenoid deposits in humans.

   “Older age, extensive ASHS-LIA, and large drusen were also associated with increased risk of incident SDDs and CNV”

   Humansin ASHS-LIA-positive eyesmean 6.2 yearsn = 144

   The Natural Course of Age-Related Scattered Hypofluorescent Spots on Late-Phase ICGA (ASHS-LIA): Structural Evolution and Neovascular Complications

   Investigative ophthalmology & visual science·Jun 1, 2026

1. ASHS-LIA raises the risk of choroidal neovascularization in humans.

   “Older age, extensive ASHS-LIA, and large drusen were also associated with increased risk of incident SDDs and CNV”

   Humansin ASHS-LIA-positive eyesmean 6.2 yearsn = 144

   The Natural Course of Age-Related Scattered Hypofluorescent Spots on Late-Phase ICGA (ASHS-LIA): Structural Evolution and Neovascular Complications

   Investigative ophthalmology & visual science·Jun 1, 2026

More on Choroidal neovascularization

1. ASHS-LIA is associated with structural progression of drusen categories in humans (OR = 2.57, P = 0.03).

   “greater ASHS-LIA extension (OR = 2.57 for grade 3 vs. 1, P = 0.03)”

   Humansin ASHS-LIA-positive eyesmean 6.2 yearsn = 144

   The Natural Course of Age-Related Scattered Hypofluorescent Spots on Late-Phase ICGA (ASHS-LIA): Structural Evolution and Neovascular Complications

   Investigative ophthalmology & visual science·Jun 1, 2026

1. ASHS-LIA predicts lipid accumulation in humans.

   “ASHS-LIA indicates the diffuse form of lipoprotein-related lipids accumulating in Bruch's membrane (BrM) throughout adulthood.”

   ReviewAMD

   Visualizing lipid behind the retina in aging and age-related macular degeneration, via indocyanine green angiography (ASHS-LIA)

   Eye (London, England)·Mar 21, 2022