Double-layer sign

1. Double-layer sign protects against geographic atrophy in humans.

   “vascularised DLS appears to protect against atrophy”

   Reviewvascularised DLS

   Predict and Protect: Evaluating the Double-Layer Sign in Age-Related Macular Degeneration

   Ophthalmology and therapy·Aug 16, 2024

More on Geographic atrophy

1. Double-layer sign is associated with choroidal neovascularization in humans.

   “The presence of a double-layer sign (DLS) was associated with CNV onset.”

   Humansin ASHS-LIA-positive eyesmean 6.2 yearsn = 144

   The Natural Course of Age-Related Scattered Hypofluorescent Spots on Late-Phase ICGA (ASHS-LIA): Structural Evolution and Neovascular Complications

   Investigative ophthalmology & visual science·Jun 1, 2026

More on Choroidal neovascularization

1. Double-layer sign raises the risk of geographic atrophy in humans.

   “non-vascularised DLS is associated with an increased risk of atrophy”

   Reviewnon-vascularised DLS

   Predict and Protect: Evaluating the Double-Layer Sign in Age-Related Macular Degeneration

   Ophthalmology and therapy·Aug 16, 2024

More on Geographic atrophy