2 papers
Compared with DNA tests, blood protein measurements scored 0.977 in one cohort and 1.000 in three others for separating variant carriers from non-carriers.Compared with DNA tests, blood protein measurements scored 0.977 in one cohort and 1.000 in three others for separating variant carriers from non-carriers.
In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.
An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.An observational study of 101 adults aged 30–85 without cognitive impairment found no overall sex differences in a small brain region’s signals or activity.
A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.A phenome-wide study of 367,757 All of Us participants linked APOE alleles to 27 phenotypes, finding ancestry-specific risks for dementia and fatty liver disease.
Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and sex.Whole-cell recordings in adult and aged humanized mice showed that APOE4 modified pyramidal cell and interneuron properties depending on both age and sex.