Anticholinergic burden

Biomarker

1 paper1 finding

Associations

1

Mortality

upin humans1HR 1.4

1 study
  1. Anticholinergic burden raises the risk of mortality in humans (HR 1.40, 95% CI 1.22-1.61).

    “Overall, pooled analysis showed a 40% higher mortality risk in patients with high anticholinergic burden (HR = 1.40; 95% CI 1.22-1.61; p < 0.001).”

    Reviewafter hip fracture

    Higher anticholinergic burden is associated with increased medium- and long-term mortality following hip fracture: A systematic review and meta-analysis

    British journal of clinical pharmacology14 Aug 2026

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