Anti-thyroid peroxidase antibodies

1. Anti-thyroid peroxidase antibodies predict diminished ovarian reserve in humans (OR = 3.13 (AMH < 1 ng/mL)).

   “Logistic regression confirmed Anti-TPO ≥ 9 IU/mL as a strong predictor of diminished ovarian reserve (AMH < 1 ng/mL: OR = 3.13; AFC < 5: OR = 6.48).”

   Humanseuthyroid infertile women, adjusted for age, BMI, and TSHfemalesn = 1,460

   Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging?

   Journal of clinical medicine·12 Nov 2025

More on Diminished ovarian reserve

1. Anti-thyroid peroxidase antibodies are associated with follicle stimulating hormone in humans (9.40 ± 6.21 vs. 8.06 ± 4.79 mIU/mL, p = 0.001).

   “elevated FSH (9.40 ± 6.21 vs. 8.06 ± 4.79 mIU/mL, p = 0.001)”

   Humanseuthyroid infertile womenfemalesn = 1,460

   Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging?

   Journal of clinical medicine·12 Nov 2025

More on Follicle stimulating hormone

1. Anti-thyroid peroxidase antibodies are associated with antral follicle count in humans (8.18 ± 5.06 vs. 15.88 ± 8.18, p < 0.0001).

   “reduced AFC (8.18 ± 5.06 vs. 15.88 ± 8.18, p < 0.0001)”

   Humanseuthyroid infertile womenfemalesn = 1,460

   Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging?

   Journal of clinical medicine·12 Nov 2025

More on Antral follicle count

1. Anti-thyroid peroxidase antibodies are associated with anti-Müllerian hormone in humans (1.47 ± 1.52 vs. 3.33 ± 3.03 ng/mL, p < 0.0001).

   “Anti-TPO positivity (17.6% prevalence) was significantly associated with reduced AMH (1.47 ± 1.52 vs. 3.33 ± 3.03 ng/mL, p < 0.0001)”

   Humanseuthyroid infertile womenfemalesn = 1,460

   Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging?

   Journal of clinical medicine·12 Nov 2025

More on anti-Müllerian hormone