Alzheimer's Disease Methylation Index

1. Alzheimer's Disease Methylation Index impairs cognitive function in humans (β range: -0.15 to -0.37, q < 0.001).

   “Higher AD-DMI scores were significantly associated with steeper decline across all domains (β range: -0.15 to -0.37, q < 0.001).”

   Humansdorsolateral prefrontal cortexup to 16 yearsn = 541

   Longitudinal Relationship Between a Novel Alzheimer’s Disease Methylation Index and Cognitive Function

   GSA 2025 abstract·31 Dec 2025

1. Alzheimer's Disease Methylation Index predicts Alzheimer's disease in humans (AUC = 0.79).

   “elastic-net logistic regression, which selected 100 CpGs that best distinguished AD cases from controls (AUC = 0.79).”

   Humansdorsolateral prefrontal cortexn = 541

   Longitudinal Relationship Between a Novel Alzheimer’s Disease Methylation Index and Cognitive Function

   GSA 2025 abstract·31 Dec 2025

More on Alzheimer's disease

1. Alzheimer's Disease Methylation Index is associated with DNA methylation in humans (β range: 0.56 to 2.13, q < 0.01).

   “AD-DMI scores were significantly associated with increasing methylation at CpGs mapped to APOE, ANK1, and HOXA3 (β range: 0.56 to 2.13, q < 0.01)”

   Humansdorsolateral prefrontal cortexup to 16 yearsn = 541

   Longitudinal Relationship Between a Novel Alzheimer’s Disease Methylation Index and Cognitive Function

   GSA 2025 abstract·31 Dec 2025

More on DNA methylation