α5β3GABAAR surface accumulation

1. Sevoflurane increases α5β3GABAAR surface accumulation in mice.

   “Sevoflurane triggered CaMKII-mediated phosphorylation at β3-S408/409, suppressing receptor internalisation and increasing surface accumulation of α5β3GABAARs (Sev vs control; P<0.0001).”

   Animalsin primary hippocampal neurones and aged mice4 vol%2 h

   Sevoflurane alters α5β3GABAA receptor trafficking via calcium/calmodulin-dependent protein kinase II-dependent β3 subunit phosphorylation to produce cognitive impairment in aged mice

   British journal of anaesthesia·27 Jan 2026

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