Age quotient

1. Age quotient mediates mortality in humans.

   “Mediation analysis supports a partial mediating role for AQ in the relationship between lifestyle factors and mortality.”

   HumansPartial mediation of the relationship between lifestyle factors and mortality

   A Blood-Based Biological Age Model Derived from Routine Laboratory Biomarkers in the Singapore Longitudinal Ageing Study

   medRxiv·6 May 2026Preprint

1. Age quotient is associated with TET2 clonal hematopoiesis burden in humans (β≈0.016 per +1 AQ year).

   “In a 57-patient subset, higher AQ was associated with increased TET2 clonal hematopoiesis burden (β≈0.016 per +1 AQ year)”

   Humans57-patient subsetn = 57

   A Blood-Based Biological Age Model Derived from Routine Laboratory Biomarkers in the Singapore Longitudinal Ageing Study

   medRxiv·6 May 2026Preprint

More on TET2 clonal hematopoiesis burden

1. Age quotient predicts mortality in humans (C-index 0.629 [SE 0.011] versus 0.606 [SE 0.011] for chronological age).

   “In overall survival discrimination, AQ outperformed chronological age (C-index 0.629 [SE 0.011] vs 0.606 [SE 0.011]), indicating superior prognostic prediction.”

   HumansSurvival discrimination compared with chronological age

   A Blood-Based Biological Age Model Derived from Routine Laboratory Biomarkers in the Singapore Longitudinal Ageing Study

   medRxiv·6 May 2026Preprint