Actigraphy PC1 activity variability and amplitude

1. Frontotemporal lobar degeneration decreases actigraphy PC1 activity variability and amplitude in humans (mean difference = -1.05, p = 0.004).

   “Post hoc Tukey HSD analysis indicated that this omnibus group difference was driven by a reduction in FTLD‐associated group PC1 scores relative to both functionally intact (mean difference=‐1.05, p = 0.004)”

   Humans

   24‐hour rest‐activity rhythms differ across Alzheimer's disease and related dementias

   AAIC 2025 abstract·23 Dec 2025

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1. Actigraphy PC1 activity variability and amplitude is associated with CDR plus NACC FTLD global score in humans (β = -0.06, p = 0.010).

   “CDR®+FTLD‐NACC global score [β=‐0.06, s.e.=0.03, p = 0.010])”

   Humanscontrolling for participant age and biological sex

   24‐hour rest‐activity rhythms differ across Alzheimer's disease and related dementias

   AAIC 2025 abstract·23 Dec 2025

More on CDR plus NACC FTLD global score

1. Actigraphy PC1 activity variability and amplitude is associated with CDR plus NACC FTLD sum of boxes in humans (β = -0.30, p = 0.010).

   “Controlling for participant age and biological sex, PC1 [activity variability and amplitude] was negatively associated with both CDR®+FTLD‐NACC sum of boxes score [β=‐0.30, s.e.=0.15 p = 0.010]”

   Humanscontrolling for participant age and biological sex

   24‐hour rest‐activity rhythms differ across Alzheimer's disease and related dementias

   AAIC 2025 abstract·23 Dec 2025

More on CDR plus NACC FTLD sum of boxes