5-methyl-2'-deoxycytidine

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Caloric restriction

downin rats1

1 study

Caloric restriction decreases 5-methyl-2'-deoxycytidine in rats.
“Levels for 5-methyl-2'-deoxycytidine (a methylated DNA breakdown product and potential marker for changes in DNA remodeling) were significantly reduced by CR only in females.”
Animalsonly in femalesskeletal muscleeight weeksfemales
Untargeted metabolomics reveals effects of calorie restriction on skeletal muscle in older female and male rats
The journals of gerontology. Series A, Biological sciences and medical sciencesJun 2, 2026

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