Sangeet Makhija

ADA loss impairs DNA repair and spurs senescence in astrocytes

Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels…Studying sporadic ALS astrocyte models, researchers found TDP43 dysfunction impaired adenosine deaminase, disrupting purines and raising P16 levels while blunting 53BP1-mediated repair.