Papers by Young Lee

83 results

  1. Communications Biology

    Disabling an enzyme shortened lifespan more in male flies

    An experiment in Drosophila flies found changes in movement, sleep and brain structure in both sexes, with more severe movement deficits in males.An experiment in Drosophila flies found changes in movement, sleep and brain structure in both sexes, with more severe movement deficits in males.

    Experiments in fliesMechanisms
  2. Biomedicine & Pharmacotherapy

    Sunitinib selectively killed senescent cells in the lab

    A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.A drug screen in human connective-tissue cells linked the selective killing effect to a protein that receives growth signals.

    Experiments in human cellsInterventions
  1. Signal Transduction and Targeted Therapy

    Inotodiol preserves muscle mass and function in aged mice

    The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.

    Experiments in miceMuscle