Papers by Qian Yang

Diabetes29 Sep
Nutrient-Sensitive Senescence Checkpoints in Diabetic Kidney Disease
ReviewKidney
Paper
Aging Cell26 Sep
Deleting liver growth hormone receptors accelerates aging phenotypes and shortens lifespan in mice
The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.The loss of hepatic growth hormone signaling disrupts lipid metabolism and causes mitochondrial damage that can be counteracted by inhibiting PDK4.
Experiments in miceGrowth hormone axis
Paper
Biochemical Pharmacology26 Sep
Sephin1 promotes mitophagy and reduces alpha-synuclein toxicity in Parkinson models
The compound directly binds Prohibitin-2 to activate PINK1-PRKN-dependent clearance of damaged mitochondria, easing motor deficits in transgenic mice.The compound directly binds Prohibitin-2 to activate PINK1-PRKN-dependent clearance of damaged mitochondria, easing motor deficits in transgenic mice.
Experiments in human cellsParkinson's disease
Paper
International Journal of Rheumatic Diseases3 Sep
Cross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank
Cohort study of 332,261 peoplePhenoAge
Paper