Research Square

Transancestral TWAS Enrichment of NMN- Informed Pathways in Type 2 Diabetes: CPT2- Linked Fatty-Acid Oxidation and MAP2K1/MAPK3 Drivers as Translational Bridges

Preprint: computational studyMechanisms

Abstract

Type 2 diabetes is a heterogeneous disease in which impaired insulin secretion, insulin resistance, altered lipid handling, and tissue-specific stress responses contribute in different proportions across individuals and populations.

The paper

Independent Researcher

Research Square, 13 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.21203/rs.3.rs-10447512/v1