Research Square
Itaconate delays type 2 diabetes progression by alkylating RIPK3 to inhibit pancreatic β‑cell failure
Preprint: experiments in animalsInterventions
Abstract
Dysregulated glucose and lipid metabolism drives β-cell failure, a central event in type 2 diabetes (T2D) pathogenesis; however, effective mechanisms to preserve β-cell mass remain elusive.
The paper
Central South University
Research Square, 10 Aug 2026, CC BY, Preprint, not peer-reviewed