Wellcome Open Res

Instrumental variable analysis applied to randomised controlled trials of glucagon-like-peptide-1 receptor agonists and bariatric surgery: A study protocol

Preprint: study protocolInterventions

Abstract

Background: Randomised controlled trials (RCTs) can be used to determine causal effect of an exposure (e.g. body mass index (BMI)) on an outcome (e.g. blood pressure (BP)) using randomisation as an instrumental variable (IV).

The paper

University of Bristol

Wellcome Open Res, 6 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.12688/wellcomeopenres.26912.1