F1000Res

Efficacy and Safety of Mazdutide for Type 2 Diabetes: a GRADE assessed systematic review and meta-analysis of randomized controlled trials

Preprint: reviewInterventions

Abstract

Background: Mazdutide, a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist, has shown promising metabolic benefits in randomized controlled trials (RCTs) of adults with type 2 diabetes mellitus (T2DM). However, its efficacy and safety have not been systematically synthesized.

The paper

Lahore Punjab Shaikh Khalifa Bin Zayed Al Nahyan Medical and Dental College; King Edward Medical University

F1000Res, 6 Aug 2026, CC BY, Preprint, not peer-reviewed

doi.org/10.12688/f1000research.186694.1