AI & dataHumans

Population-scale immune multiome atlas reveals regulatory disease mechanisms

Nature

The paper

Masahiro Kanai, Toni Marie Delorey, Honkanen Jarno,
Show 483 more authorsRodosthenis S. Rodosthenous, Julianna Juvila, Shane Murphy, Isabella Teixeira-Soldano, Hee Seung Hwang, Juha Karjalainen, Jussi Halonen, Georgia Panagiotaropoulou, Yuanxiang Zhang, Cristin McCabe, Eric Chen, コウサク ナンキ, Toshimi Yoshida, Kai Liu, Marla Glean, Nitya Mehrotra, Emily P. Finan, Daniel Chafamo, Yixiao Zhu, Mikko Arvas, Sanni Ruotsalainen, Zhili Zheng, Yoshihiko Tomofuji, Daiki Tokuyasu, Shinichi Namba, Kyuto Sonehara, Biobank Japan Project, Koichi Matsuda, Takayuki Morisaki, Natsuhiko Kumasaka, Akiko Nagai, Norihiro Harada, Sonoko Harada, Yasunobu Nagata, Satoshi Wakita, Hiroki Yamaguchi, FinnGen, Mark J. Daly, Pharmaceutical companies, Bridget Riley-Gillis, Howard Jacob, Coralie Viollet, Slavé Petrovski, Alix Berton, Santha Ramakrishnan, Ellen Tsai, Zhihao Ding, Emily Holzinger, Robert Plenge, Joseph Maranville, Mark McCarthy, Rion Pendergrass, Jonathan Davitte, Chia-Yen Chen, Melis Atalar Aksit, Anna Vlahiotis, Katherine Klinger, Clément Chatelain, Jörg Blankenstein, Karol Estrada, Robert Graham, Dawn Waterworth, Chris O’Donnell, Nicole Renaud, Tomi P. Mäkelä, Jaakko Kaprio, Minna Ruddock, Lila Kallio, Antti Hakanen, Terhi Kilpi, Markus Perola, Taneli Raivio, Eero Punkka, Teija Kekonen, Raisa Serpi, Kati Kristiansson, Sanna Siltanen, Veli-Matti Kosma, Arto Mannermaa, Jari Laukkanen, Tiina Jokela, Mervi Ahlroth, Johanna Mäkelä, Other Experts/Non-Voting Members, Outi Tuovila, Pharmaceutical companies, Jeffrey Waring, Bridget Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Marc Jung, Hanati Tuoken, Shameek Biswas, Benjamin Sun, Neha Raghavan, Sul Jae-Hoon, Xinli Hu, Ma'en Obeidat, Jonathan Chung, Jonas Zierer, Mari Niemi, Samuli Ripatti, Johanna Schleutker, Tiina Wahlfors, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Katriina Aalto‐Setälä, Mika Kähönen, Johanna Mäkelä, Hanna Kujala, Triin Laisk, Natalia Pujol, Veikko Salomaa, Jaana Suvisaari, Satu Koskela, Jouni Lauronen, Kristiina Aittomäki, Pirkko Pussinen, Tuomo Meretoja, Heikki Joensuu, Peeter Karihtala, Emma Juuri, Aino Salminen, Prof. Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Fredrik Åberg, Daniel Gordin, Patrik Finne, Joni A. Turunen, Minna Raivio, Pentti Tienari, Martti Färkkilä, Jukka Koskela, Sampsa Pikkarainen, Kari Eklund, Paula Kauppi, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Johanna Mattson, Eveliina Salminen, Terhi Ollila, Katariina Hannula-Jouppi, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Erkki Isometsä, Antti Aarnisalo, Ilkka Immonen, Salla Ranta, Filip Scheperjans, Felix Vaura, Nina Mars, Esa Pitkänen, Hannele Laivuori, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Hanna Ollila, Elmo Saarentaus, Anne Kerola, Eero Vuoksimaa, Joni Lindbohm, Zhiyu Yang, Matthew Sampson, Adrian Banerji, Michelle McNulty, Aoxing Liu, Joel Rämö, Austin Argentieri, Amanda Elliott, Elisa Rahikkala, Kirsi Sipilä, Valtteri Julkunen, Ville Leinonen, Sanna Toppila-Salmi, Mikko Hiltunen, Eino Solje, Hannu Kankaanranta, Antti Mäkitie, Iiris Hovatta, Niko Välimäki, Minttu Marttila, Anne Portaankorva, Eija Laakkonen, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Riitta Kaarteenaho, Jaakko Tyrmi, Laura Kuusalo, Laura Pirilä, Tapio Hellman, Matti Vuori, Teemu Niiranen, Timo Blomster, Johanna Huhtakangas, Terttu Harju, Kaisa Tasanen, Laura Huilaja, Vuokko Anttonen, Marja Vääräsmäki, Outi Uimari, Laure Morin-Papunen, Maarit Niinimäki, Terhi Piltonen, Reetta Kälviäinen, Hilkka Soininen, Mikko Kiviniemi, Oili Kaipiainen-Seppänen, Margit Pelkonen, Päivi Auvinen, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Kai Kaarniranta, Jukka Peltola, Airi Jussila, Katri Kaukinen, Pia Isomäki, Jussi Hernesniemi, Annika Auranen, Hannu Uusitalo, Teea Salmi, Venla Kurra, Laura Kotaniemi‐Talonen, Argyro Bizaki-Vallaskangas, Juha Rinne, Roosa Kallionpää, Markku Voutilainen, Antti Palomäki, Riitta Lahesmaa, Kaj Metsärinne, Jenni Aittokallio, Klaus Elenius, Sirkku Peltonen, Leena Koulu, Ulvi Gursoy, Varpu Jokimaa, Tytti Willberg, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Apinya Lertratanakul, Relja Popovic, Mengzhen Liu, Anneke Den Hollander, Jan Freudenberg, Britney Milkovich, Andrew Blumenfeld, Tushar Kumar, Dirk Paul, Bram Prins, Eleanor Wheeler, Kousik Kundu, Santosh Atanur, Andrew Lowe, Thomas Spargo, Oliver Burren, Margarete Fabre, Fabio Baschiera, Hans van Leeuwen, Himanshu Manchanda, Karl Heilbron, Martin Rao, Nicole Schmidt, Samu Kurki, Johanna Mielke, Juho Immonen, Thomas Battram, Tobias Hogrebe, Susan Eaton, Ketian Yu, Stephanie Loomis, Coro Paisan-Ruiz, Elke Markert, Frank Li, Yao Hu, Christoph Ogris, Eric Simon, Julio Cesar Bolivar Lopez, Monika Frysz, Marla Hochfeld, Cara Carty, Michael Turchin, Neelakshi Jog, Corneliu Bodea, Janie Shelton, Chen Li, K. Singh, Peng Jiang, Stephanie Loomis, Elena Sanchez, Lilith Moss, Zijie Zhao, Anna Podgornaia, Natalie Bowers, Edmond Teng, Tim Lu, Hubert Chen, Jennifer Schutzman, Erich Strauss, Hao Chen, David Choy, Brian Yaspan, Cameron Adams, Michael Rothenberg, Sergio Dellepiane, Anubha Mahajan, Michael Holmes, Diana Chang, Tushar Bhangale, Fanli Xu, Laura Addis, John Eicher, Linda McCarthy, Jorge Esparza Gordillo, Joanna Betts, Rajashree Mishra, Audrey Chu, Diptee Kulkarni, Janet Kumar, Charli Harlow, Lea Sarow-Blat, Diana L. Cousminer, Jagtar Nijjar, Jessica Chao, Michal Magid, Shashank Jariwala, Chris Floyd, Dan Swerdlow, Erding Hu, Prerak Desai, Stephen Haddad, Damien Croteau-Chonka, Billy Fahy, Paola Bronson, Kirsi Auro, David Pulford, Sauli Vuoti, Dermot Reilly, Karen He, Ekaterina Khramtsova, Amy Hart, Meijian Guan, Alessandro Porello, P. Dunnmon, Sara Gale, Brice Keyes, John Kwon, Jonathan Sherlock, Matt Loza, Chris Whelan, W. Galpern, Yanfei Zhang, Mona Selej, Abolfazl Doostparast Torshizi, Qingqin S. Li, Sahar Mozaffari, Christopher Deboever, Jason Miller, Fabiana Farias, Andrey Loboda, Jorge Del-Aguila, Elisabeth Vollmann, József Kármán, Julie Fiore, Rajesh Kamath, Andrei Popescu, Delphine Fagegaltier, Travis Barr, Aristide Merola, Oliver Freeman, Simonne Longerich, Enrico Ferrero, Nikos Patsopoulos, Nancy Finkel, Sabina Pfister, Shola Richards, Katherine McCauley, Xiaobo Xia, Mike Mendelson, Majd Mouded, Debby Ngo, Kirsi Kalpala, Melissa Miller, Nan Bing, Jaakko Parkkinen, Heli Lehtonen, Stefan McDonough, Ying Wu, Erin Macdonald-Dunlop, Jessica Chung, Michael McLean, Joshua Chiou, Hye In Kim, Sivakumar Pitchumani, Sumedha Jassal, Madhurima Saxena, Catherine O’Riordan, Samuel Lessard, Suzanne Jacobs, Hamid Mattoo, David Habiel, Guanling Huan, Biobank directors, FinnGen Teams, Administration, Anu Jalanko, Risto Kajanne, Mervi Aavikko, Helen Cooper, Denise Öller, Tarja Laitinen, Sofia Kuitunen, Sample and data logistics, Auli Toivola, Rodosthenis S. Rodosthenous, Analysis, Pietro Della Briotta Parolo, Arto Lehisto, Juha Mehtonen, Reza Jabal, Mutaamba Maasha, Samuel Jones, Raymond Walters, Paavo Häppölä, Disease Task Forces, L. Elisa Lahtela, Johanna Paltta, Juulia Partanen, Communication, Mari Kaunisto, Sandbox and Cloud Services, Elina Kilpeläinen, Tianduanyi Wang, Timo Petteri Sipila, Oluwaseun Alexander Dada, Awaisa Ghazal, Rigbe Weldatsadik, Jaska Uimonen, Genotyping, Kati Donner, Sample Collection Coordination, Anu Loukola, Sample and data logistics, Päivi Laiho, Registry Data Operations, Susanna Lemmelä, Teemu Paajanen, Arto Pietilä, Aki Havulinna, Phenotype team, Mary Pat Reeve, Shanmukha Sampath Padmanabhuni, Harri Siirtola, Javier Gracia Tabuenca, Marika Kaakinen, Shuang Luo, Vincent Llorens, Dawit Yohannes, Data protection officer, Iina Laak, FINBB—Finnish Biobank Cooperative, Pauli Wihuri, Tom Southerington, Meri Lähteenmäki, Yukinori Okada, Mary Pat Reeve, Mitja Kurki, Caroline B. M. Porter, Orr Ashenberg, Wei Zhou, Kimmo Pitkänen, Jukka Partanen, Aarno V. Palotie, Daniel B. Graham, Mark J. Daly,
Ramnik J. Xavier

Broad Institute

Nature · 30 Sep 2026

doi.org/10.1038/s41586-026-11078-2PubMed 42816628