Probe-Based Confocal Laser Endomicroscopy During Immune Checkpoint Inhibitor Therapy: A Translational Framework Linking Intestinal Barrier Function, Microbiota, and Clinical Outcomes

Nutrients

Abstract

Immune checkpoint inhibitors (ICIs) have transformed the treatment of several malignancies, but their efficacy and gastrointestinal (GI) immune-related adverse events (irAEs) vary considerably among patients.

The paper

Paola Spessotto, Francesca Orbosuè, Maurizio Mongiat,

Stefania Maiero, Marco Sartori, Michela Guardascione, Luisa Foltran, Arianna Fumagalli, Marco de Scordilli, Alessandra Bearz, Lucia Fratino, Silvia Bolzonello, Michele Spina, Fabio Puglisi, Vincenzo Canzonieri, Renato Cannizzaro, Riccardo Dolcetti, Elena Ongaro,

Stefano Realdon

Centro di Riferimento Oncologico

Nutrients · 20 Sep 2026 · CC BY

doi.org/10.3390/nu18183086 PubMed 42797069

Probe-Based Confocal Laser Endomicroscopy During Immune Checkpoint Inhibitor Therapy: A Translational Framework Linking Intestinal Barrier Function, Microbiota, and Clinical Outcomes

Abstract

The paper

Computer model detected fractures and located bones in spine scans

Model uses blood pressure swings to better distinguish risk

Gap between predicted and actual age linked to death risk

Routine data helped target frailty checks in chronic disease

Probe-Based Confocal Laser Endomicroscopy During Immune Checkpoint Inhibitor Therapy: A Translational Framework Linking Intestinal Barrier Function, Microbiota, and Clinical Outcomes

Abstract

The paper

More in Biomarkers