Genetic study links protein inhibition to lower kidney disease risk

Genetic proxies for inhibiting angiopoietin-like proteins 3 and 4, which regulate blood fats, were associated with lower kidney disease odds and higher estimated kidney filtration rates. Per one-standard-deviation decrease in triglycerides, a blood fat, the odds ratios were 0.76 and 0.78, respectively. An odds ratio below 1 indicates lower odds; a standard deviation describes variation in a measure. Genetically proxied enhancement of lipoprotein lipase, a fat-processing enzyme, was also associated with lower disease odds, with an odds ratio of 0.86 on the same scale, and higher estimated filtration rates.